Evidence for a multivalent effect in inhibition of sulfatases involved in lysosomal storage disorders (LSDs). Issue 69 (11th July 2016)
- Record Type:
- Journal Article
- Title:
- Evidence for a multivalent effect in inhibition of sulfatases involved in lysosomal storage disorders (LSDs). Issue 69 (11th July 2016)
- Main Title:
- Evidence for a multivalent effect in inhibition of sulfatases involved in lysosomal storage disorders (LSDs)
- Authors:
- D'Adamio, G.
Matassini, C.
Parmeggiani, C.
Catarzi, S.
Morrone, A.
Goti, A.
Paoli, P.
Cardona, F. - Abstract:
- Abstract : New targets sensitive to multivalency: synthesis of nonavalent pyrrolidine iminosugars. Abstract : Two newly synthesized nonavalent polyhydroxylated pyrrolidine iminosugars are the first examples of multivalent inhibitors of GALNS and IDS lysosomal enzymes, whose deficiency leads to Morquio A syndrome and Hunter disease, respectively, and pave the way to a pharmacological chaperone or stabilizing enzyme therapy for these LSDs.
- Is Part Of:
- RSC advances. Volume 6:Issue 69(2016)
- Journal:
- RSC advances
- Issue:
- Volume 6:Issue 69(2016)
- Issue Display:
- Volume 6, Issue 69 (2016)
- Year:
- 2016
- Volume:
- 6
- Issue:
- 69
- Issue Sort Value:
- 2016-0006-0069-0000
- Page Start:
- 64847
- Page End:
- 64851
- Publication Date:
- 2016-07-11
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/RA ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6ra15806d ↗
- Languages:
- English
- ISSNs:
- 2046-2069
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8036.750300
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1046.xml