Oleiferasaponin C6 from the seeds of Camellia oleifera Abel.: a novel compound inhibits proliferation through inducing cell-cycle arrest and apoptosis on human cancer cell lines in vitro. Issue 94 (26th September 2016)

• Record Type: Journal Article
• Authors: Zong, Jianfa; Wang, Dongxu; Jiao, Weiting; Zhang, Liang; Bao, Guanhu; Ho, Chi-Tang; Hou, Ruyan; Wan, Xiaochun
• Is Part Of: RSC advances. Volume 6:Issue 94(2016)
• Page Start: 91386
• Page End: 91393
• Publication Date: 2016-09-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra14467e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Oleiferasaponin C6 was isolated from Camellia oleifera Abel. and inhibits proliferation through inducing cell-cycle arrest and apoptosis on cancer cell lines in vitro . Abstract : A new oleanane-type saponin oleiferasaponin C6 (OSC6 ) was isolated and identified from Camellia oleifera seeds through NMR, HR-ESI-MS, and GC-MS spectroscopic methods. This new oleanane-type saponin exhibits potent cytotoxic activities on five human cancer cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB), especially in HL-60 and BEL-7402 cell lines. The action mechanism of the anti-cancer activity of OSC6 was further investigated and it showed significant induction of cell cycle arrest and apoptosis in HL-60 and BEL-7402 cell lines by down-regulating CDK4, cyclin D1 and Bcl-2; up-regulating p21, caspase-3/9, p-p53 and Bax protein expression in vitro . These results suggested that the newly isolated saponin OSC6 is a potential therapeutic agent for the treatment of human cancer.