Self-propelled manganese oxide-based catalytic micromotors for drug delivery. Issue 70 (11th July 2016)

• Record Type: Journal Article
• Authors: Wang, Linlin; Chen, Jun; Feng, Xiaomiao; Zeng, Wenjin; Liu, Ruiqing; Xiujing Lin, ; Ma, Yanwen; Wang, Lianhui
• Is Part Of: RSC advances. Volume 6:Issue 70(2016)
• Page Start: 65624
• Page End: 65630
• Publication Date: 2016-07-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra13739c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel self-propelled drug delivery vehicle was developed to capture and transport an anticancer drug through electrostatic interactions. Abstract : A manganese oxide-based catalytic tubular micromotor (PEDOT/MnO2 ) is described that displays effective autonomous motion in hydrogen peroxide with high speed (318.80 µm s −1 ) and can operate in very low levels of fuel, down to 0.4%. The polymer bilayer micromotor also exhibits efficient locomotion in different biological media including bovine serum albumin and bovine serum. Moreover, the micromotor is applied to deliver a chemotherapeutic anticancer drug, camptothecin, using electrostatic interactions, offering considerable potential for diverse clinical and biomedical applications such as drug delivery for theranostic microsystems.