New alkaloids from Daphniphyllum himalense. Issue 50 (5th May 2016)

• Record Type: Journal Article
• Authors: Zhang, Hua; Zhang, Dong-Dong; Li, Jing-Ya; Shyaula, Sajan L.; Li, Jia; Yue, Jian-Min
• Is Part Of: RSC advances. Volume 6:Issue 50(2016)
• Page Start: 44402
• Page End: 44409
• Publication Date: 2016-05-05
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra06420e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A series of Daphniphyllum alkaloids with selective kinase inhibitory activity were isolated and structurally characterized from Daphniphyllum himalense . Abstract : Nine new Daphniphyllum alkaloids (1–9 ) and 16 biosynthetically related known ones were obtained during the phytochemical investigation into a Nepalese plant, Daphniphyllum himalense . Structures were assigned to these compounds based on careful spectroscopic interpretation and NMR comparison with literature data. Deuteration of H2 -16 in CD3 OD due to quick keto-enol tautomerization was observed for both2 and3 . The recently reported 3β-hydroxydaphniyunnine A was re-examined and its structure was revised to be 21-deoxymacropodumine D via X-ray diffraction analysis. All the isolates were screened preliminarily for their in vitro inhibitory effects against four kinases, PTP1B, aurora A, HDAC6 and IKK-β, and selective alkaloids exhibited weak activities at 20 μg mL −1 .