A unified approach to pyrrole-embedded aza-heterocyclic scaffolds based on the RCM/isomerization/cyclization cascade catalyzed by a Ru/B-H binary catalyst system. Issue 41 (7th April 2016)

• Record Type: Journal Article
• Authors: Inamdar, Suleman M.; Chakrabarty, Indradweep; Patil, Nitin T.
• Is Part Of: RSC advances. Volume 6:Issue 41(2016)
• Page Start: 34428
• Page End: 34433
• Publication Date: 2016-04-07
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra05646f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An easy and straightforward preparation of pyrrole-embedded aza-heterocyclic scaffolds employing a Ru/B-H binary catalyst system has been developed. Abstract : An easy and straightforward preparation of pyrrole-embedded aza-heterocyclic scaffolds employing a Ru/B-H binary catalyst system has been developed. The strategy generates a diverse array of privileged scaffolds from 2-aminophenyl group appended pyrroles that can be prepared by a two-step process from corresponding aminoaryl-substituted pyrroles. The technique of incorporating 2-aminoaromatic groups in the heterocycles and their subsequent ring-closing-metathesis (RCM) isomerization followed by subsequent Pictet–Spengler type reaction should also be applicable to other heterocycles for generating a library of multi-ring compounds in an efficient manner.