A metal-free cyclic iminium induced one-pot double annulation cascade: access to dihydroisoquinolinium (DHIQ) salts. Issue 44 (26th October 2016)

• Record Type: Journal Article
• Authors: Sagar, A.; Nagarjuna Babu, Venkata; Shinde, Anand H.; Sharada, Duddu S.
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 44(2016)
• Page Start: 10366
• Page End: 10370
• Publication Date: 2016-10-26
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02089e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A reactive cyclic iminium induced one-pot Groebke–Blackburn–Bienayme (GBB) double annulation cascade (DAC) for the synthesis of skeletally diverse DHIQ salts has been described. The key features of this protocol are solvent-free, robust method, clean reaction profile and operational simplicity. Abstract : A reactive cyclic iminium induced one-pot Groebke–Blackburn–Bienayme (GBB) double annulation cascade (DAC) for the synthesis of skeletally diverse DHIQ salts has been described. The key features of this protocol are transition-metal and solvent-free, mild reaction conditions, robust method, one-step construction of two privileged heterocyclic rings, clean reaction profile and operational simplicity.