A CoII complex for 19F MRI-based detection of reactive oxygen species. Issue 96 (14th November 2016)

• Record Type: Journal Article
• Authors: Yu, Meng; Xie, Da; Phan, Khanh P.; Enriquez, José S.; Luci, Jeffrey J.; Que, Emily L.
• Is Part Of: Chemical communications. Volume 52:Issue 96(2016)
• Page Start: 13885
• Page End: 13888
• Publication Date: 2016-11-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc08207f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A fluorinated, cobalt(ii )-based 19 F MRI imaging agent switches from a paramagnetic high spin Co II state to a diamagnetic low spin Co III state following oxidation by H2 O2 and other reactive oxygen species, resulting in a turn-on response via both 19 F NMR and MRI. Abstract : A fluorinated, air-stable cobalt(ii ) complex serves as a turn-on 19 F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2 O2 . Upon oxidation with H2 O2, the complex converts from paramagnetic high spin Co II to diamagnetic low spin Co III resulting in a chemical shift change and enhancement in 19 F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na2 S2 O4 . The turn-on response is demonstrated by 19 F MRI, characterized by a ∼2–3 fold enhancement in signal.