Green silver nanoparticles for drug transport, bioactivities and a bacterium (Bacillus subtilis)-mediated comparative nano-patterning feature. Issue 52 (11th May 2016)

• Record Type: Journal Article
• Authors: Dey, B.; Mukherjee, S.; Mukherjee, N.; Mondal, R. K.; Satpati, B.; Senapati, D.; Babu, S. P. Sinha
• Is Part Of: RSC advances. Volume 6:Issue 52(2016)
• Page Start: 46573
• Page End: 46581
• Publication Date: 2016-05-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra27886d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Supramolecular hydrogel-capped non-toxic Ag NPs are effective for cellular drug transport and are potentially bioactive, which also leads to the formation of novel silver nanoparticles. Abstract : The 'green' synthetic aspects of functionally potent and biologically relevant nanomaterials are a crucial research objective. Pursuing this concept, we have investigated a green synthetic scheme for the sunlight-mediated generation of luminescent silver nanoparticles, which become stabilized via a supramolecular hydrogel (SHGel) network, as already reported by our group. In vitro and in vivo toxicity studies confirm the biologically relevant nature of SHGel-capped Ag NPs. Nontoxic SHGel-capped Ag NPs were intelligently used for the transport of drugs, including antifilarial and antibiotic agents, into cells. Apart from this activity, SHGel-capped Ag NPs and our previously reported nontoxic DNA hydrogel-capped Ag NPs are potent against pathogens and parasites. Most interestingly, the nanostructural patterns of SHGel- and DNA hydrogel-capped Ag NPs have been transformed into cotyledon- and flower bud-shaped forms of nanosilver, respectively, during their chemotherapeutic action against a particular bacterium, Bacillus subtilis . Transmission electron microscopy was used for the visualization of several patterns of nanosilver and the incorporation of Ag NPs into macrophages.