Translational PK/PD of anti-infective therapeutics. (September 2016)

• Record Type: Journal Article
• Authors: Rathi, Chetan; Lee, Richard E.; Meibohm, Bernd
• Is Part Of: Drug discovery today. Volume 21/22(2016)
• Page Start: 41
• Page End: 49
• Publication Date: 2016-09
• Subjects: Drug development -- Periodicals; Physiology, Pathological -- Periodicals; Drugs -- Design -- Periodicals; 615.1
• DOI: 10.1016/j.ddtec.2016.08.004
• Languages: English
• ISSNs: 1740-6749

Abstract

Abstract : Translational PK/PD modeling has emerged as a critical technique for quantitative analysis of the relationship between dose, exposure and response of antibiotics. By combining model components for pharmacokinetics, bacterial growth kinetics and concentration-dependent drug effects, these models are able to quantitatively capture and simulate the complex interplay between antibiotic, bacterium and host organism. Fine-tuning of these basic model structures allows to further account for complicating factors such as resistance development, combination therapy, or host responses. With this tool set at hand, mechanism-based PK/PD modeling and simulation allows to develop optimal dosing regimens for novel and established antibiotics for maximum efficacy and minimal resistance development.