Leptin as immune mediator: Interaction between neuroendocrine and immune system. (January 2017)

• Record Type: Journal Article
• Authors: Procaccini, Claudio; La Rocca, Claudia; Carbone, Fortunata; De Rosa, Veronica; Galgani, Mario; Matarese, Giuseppe
• Is Part Of: Developmental and comparative immunology. Volume 66(2017)
• Page Start: 120
• Page End: 129
• Publication Date: 2017-01
• Subjects: Leptin -- Innate immunity -- Adaptive immunity -- Non-mammalian vertebrates; Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2016.06.006
• Languages: English
• ISSNs: 0145-305X

Abstract

Abstract: Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin has subsequently been shown to exert pleiotropic effects, being also able to influence haematopoiesis, thermogenesis, reproduction, angiogenesis, and more importantly immune homeostasis. As a cytokine, leptin can affect both innate and adaptive immunity, by inducing a pro-inflammatory response and thus playing a key role in the regulation of the pathogenesis of several autoimmune/inflammatory diseases. In this review, we discuss the most recent advances on the role of leptin as immune-modulator in mammals and we also provide an overview on its main functions in non-mammalian vertebrates. Highlights: Leptin regulates function of macrophages, dendritic cells, NK cells, neutrophils, eosinophils and basophils. Leptin increases and sustains CD4 + T cells function. Leptin is a negative signal for Treg cells function. Leptin regulates function of macrophages, dendritic cells, NK cells, neutrophils, eosinophils and basophils.