Clinical periodontal status and inflammatory cytokines in gestational diabetes mellitus. (December 2016)

• Record Type: Journal Article
• Authors: Özçaka, Özgün; Ceyhan-Öztürk, Banu; Gümüş, Pınar; Akcalı, Aliye; Nalbantsoy, Ayşe; Buduneli, Nurcan
• Is Part Of: Archives of oral biology. Volume 72(2016)
• Page Start: 87
• Page End: 91
• Publication Date: 2016-12
• Subjects: Diabetes, gestational -- Tumour necrosis factor-alpha -- Interleukin-10 -- Interleukin-33, gingival disease -- Gingival crevicular fluid -- Serum; Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2016.08.012
• Languages: English
• ISSNs: 0003-9969

Abstract

Highlights: We hypothesized that maternal gingival inflammation could induce a systemic inflammatory response causing insulin resistance. We examine changes in the level of GCF IL-10 concentrations in the GDM women. Clinical periodontal parameters seems to be more pronounced in women with GDM. The present finding of higher serum TNF-α levels in the non-GDM group is rather unexpected. Abstract: Objectives: The aim of the present cross-sectional study was to compare clinical periodontal findings as well as gingival crevicular fluid (GCF) and serum levels of tumour necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), and IL-33 between women with and without gestational diabetes mellitus (GDM). Methods: Serum and GCF samples were collected, full-mouth recordings comprising plaque index, bleeding on probing and probing depth were performed in 96 females with GDM (cases) and 65 non-diabetic pregnant females (controls). Age, smoking status, pre-pregnancy body mass index, pregnancy outcomes were recorded. Serum and GCF IL-10, IL-33, TNF-α levels were determined. Results: The GDM group was significantly older than the control group with an age difference of 3.27 years (mean ages were 32.05 and 28.78 years, respectively) (p < 0.0001). Plaque Index (50.0 and 30.0 p = 0.005), bleeding on probing (50.0 and 30.0 p = 0.003) values were significantly higher in the GDM group. Serum TNF-α concentrations were significantly higher in the nonGDM group than the GDM group (p = 0.001). GCF IL-10 concentrations and total amounts were significantly higher in the GDM group than the controls (p = 0.004 and p < 0.0001, respectively). Conclusion: Elevated GCF IL-10 levels may be a consequence of higher levels of inflammation as indicated by higher PI and BOP in the GDM group. However, the investigated clinical parameters may not have prominent effects on TNF-α and IL-33 levels. These findings provide further support for the importance of periodontal health during pregnancy.