An aniline bearing hemicyanine derivative serves as a mitochondria selective probe. (January 2017)

• Record Type: Journal Article
• Authors: Lee, Dayoung; Jung, Min-Kyo; Yin, Jun; Kim, Gyoungmi; Pack, Chan-Gi; Yoon, Juyoung
• Is Part Of: Dyes and pigments. Volume 136(2017)
• Page Start: 467
• Page End: 472
• Publication Date: 2017-01
• Subjects: Fluorescent probe -- Mitochondria selective probe -- Fluorescent sensor -- Mitochondria staining probe; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2016.09.010
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe.HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by usingHCA-Mito . Highlights: A new hemicyanine derivative (HCA-Mito ) is reported as a new mitochondria staining probe. HCA-Mito can be synthesized in two steps. HCA-Mito selectively stains mitochondria. HCA-Mito successfully stains the fibrous structures of mitochondria.