APOL1‐Associated End‐Stage Renal Disease in a Living Kidney Transplant Donor. Issue 12 (6th October 2016)

• Record Type: Journal Article
• Authors: Zwang, N. A.; Shetty, A.; Sustento‐Reodica, N.; Gordon, E. J.; Leventhal, J.; Gallon, L.; Friedewald, J. J.
• Is Part Of: American journal of transplantation. Volume 16:Issue 12(2016:Dec.)
• Page Start: 3568
• Page End: 3572
• Publication Date: 2016-10-06
• Subjects: clinical research/practice -- kidney transplantation/nephrology -- organ transplantation in general -- pathology/histopathology -- donors and donation: living -- donor nephrectomy -- donors and donation: donor follow‐up; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.14035
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Homozygosity for apolipoprotein‐L1 ( APOL1 ) risk variants has emerged as an important predictor of renal disease in individuals of African descent over the past several years. Additionally, these risk variants may be important predictors of renal allograft failure when present in a living or deceased donor. Currently, there is no universal recommendation for screening of potential donors. We present a case of end‐stage renal disease with focal segmental glomerulosclerosis in a living donor 7 years following donor nephrectomy. Genetic assessment revealed homozygosity for the G1 high‐risk APOL1 variant. Abstract : The authors present a case of end‐stage renal disease in a living kidney donor 7 years after donor nephrectomy who was found to be homozygous for the G1 high‐risk apolipoprotein‐L1 variant.