Low startle magnitude may be a behavioral marker of vulnerability to cocaine addiction. Issue 1 (18th November 2016)

• Record Type: Journal Article
• Authors: Wheeler, Marina G.; Duncan, Erica; Davis, Michael
• Is Part Of: Synapse. Volume 71:Issue 1(2017)
• Page Start: 46
• Page End: 50
• Publication Date: 2016-11-18
• Subjects: acoustic startle -- cocaine -- dopamine -- novelty preference -- self‐administration; Synapses -- Periodicals; 612
• DOI: 10.1002/syn.21943
• Languages: English
• ISSNs: 0887-4476

Abstract

Abstract: Cocaine addicted men have low startle magnitude persisting during prolonged abstinence. Low startle rats show greater cocaine self‐administration than high startle rats. Low startle may be a marker of a vulnerability to heightened cocaine‐related behaviors in rats and similarly may be a marker of vulnerability to cocaine addiction in humans. Abstract : Cocaine addicted men have low startle magnitude persisting during prolonged abstinence. Low startle rats show greater cocaine self‐administration than high startle rats. Low startle may be a marker of a vulnerability to heightened cocaine‐related behaviors in rats and similarly may be a marker of vulnerability to cocaine addiction in humans.