Catalytic Thiourea Promoted Electrophilic Thiocyanation of Indoles and Aromatic Amines with NCS/NH4SCN. Issue 11 (24th October 2016)

• Record Type: Journal Article
• Authors: Wang, Cancan; Wang, Zhonghao; Wang, Liang; Chen, Qun; He, Mingyang
• Is Part Of: Chinese journal of chemistry. Volume 34:Issue 11(2016:Nov.)
• Page Start: 1081
• Page End: 1085
• Publication Date: 2016-10-24
• Subjects: thiocyanation -- indoles -- aromatic amines -- catalytic thiourea -- N‐chlorosuccinimide; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201600344
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract: A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4 SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily available organocatalyst. Moreover, N ‐chlorosuccinimide (NCS) was found to be indispensable, and thiourea could greatly promote the reaction. Abstract : A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4 SCN system has been developed.