Drug Delivery: Breaching the Hyaluronan Barrier with PH20‐Fc Facilitates Intratumoral Permeation and Enhances Antitumor Efficiency: A Comparative Investigation of Typical Therapeutic Agents in Different Nanoscales (Adv. Healthcare Mater. 22/2016). Issue 22 (November 2016)

• Record Type: Journal Article
• Authors: Liu, Shan; Wei, Wei; Xie, Bo; Yue, Hua; Ni, Dezhi; Bao, Yali; Ma, Guanghui; Su, Zhiguo G.
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 22(2016)
• Page Start: 2835
• Page End: 2835
• Publication Date: 2016-11
• Subjects: doxorubicin -- gold nanorods -- novel drug delivery systems -- trastuzumab -- tumor microenvironment and modification; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201670118
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : On page 2872, Guanghui Ma, Zhiguo Su, and co‐workers construct a long‐acting hyaluronidase (PH20‐Fc) as a diffusion facilitator for typical anticancer agents: doxorubicin, trastuzumab, and gold nanorod. Although effective, the performances vary among these therapeutic agents. Trastuzumab benefits most from PH20‐Fc with a best improvement in penetration and accumulation. Their systematic investigations thus reveal the importance of therapeutics size effect when using diffusion facilitator for anticancer therapy.