Copolymer‐Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo. Issue 22 (26th September 2016)

• Record Type: Journal Article
• Authors: Crowder, Spencer W.; Balikov, Daniel A.; Boire, Timothy C.; McCormack, Devin; Lee, Jung Bok; Gupta, Mukesh K.; Skala, Melissa C.; Sung, Hak‐Joon
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 22(2016)
• Page Start: 2866
• Page End: 2871
• Publication Date: 2016-09-26
• Subjects: angiogenesis -- cell–material interface -- inflammation -- mesenchymal stem cells -- outside‐in signaling -- synthetic copolymers; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201600819
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Material‐induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell‐repellent and cell‐adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.