The clinical and biochemical characteristics associated with insulin resistance in non-obese young women*. (1st September 2016)

• Record Type: Journal Article
• Authors: Wang, Ching-Chiung; Chang, Chun-Jen; Hsu, Ming-I
• Is Part Of: Gynecological endocrinology. Volume 32:Number 9(2016:Sep.)
• Page Start: 767
• Page End: 771
• Publication Date: 2016-09-01
• Subjects: Androgens -- insulin resistance -- non-obesity -- PCOS -- TSH; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2016.1163671
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Aim : The aim of this study was to investigate the biomarkers of insulin resistance in non-obese women. Design : This was a retrospective study. Patients : A total 229 non-obese women (Body mass index: BMI < 25) were evaluated. Main outcome measure(s) : Serum levels of various androgens, cardiovascular risk and metabolic components. Results : There were no significant differences in the prevalence of polycystic ovary syndrome (PCOS), hyperprolactinemia, or premature ovarian failure (POF) between the non-obese women with and without insulin resistance. Non-obese women with insulin had significantly higher serum thyroid stimulation hormone (TSH) levels and resistin and lower serum adiponectin levels than non-obese women without insulin resistance; however, the inflammatory biomarkers and serum androgen levels did not differ between the two groups. Furthermore, using step-wise multivariate regression analysis applied by the risk factors listed above, TSH was the only predictive factor for insulin resistance in non-obese reproductive-aged women. Conclusions : Thyroid function should play an important role in developing insulin resistance for non-obese women. Serum androgens and inflammation might not contribute to insulin resistance in these women.