Retroviral restriction: nature's own solution. Issue 6 (December 2016)

• Record Type: Journal Article
• Authors: Jones, Christopher E.; McKnight, Áine
• Is Part Of: Current opinion in infectious diseases. Volume 29:Issue 6(2016)
• Page Start: 609
• Page End: 614
• Publication Date: 2016-12
• Subjects: anti-HIV therapies -- HIV -- host-mediated immunity -- restriction factors; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Review Literature -- Periodicals; 616.905
• DOI: 10.1097/QCO.0000000000000322
• Languages: English
• ISSNs: 0951-7375

Abstract

Abstract : Purpose of review: The present review will discuss recent advances in the development of anti-HIV therapies inspired by studies of the mechanisms of host restriction factor-mediated resistance to HIV infection. Recent findings: Manipulating the interplay between host cell restriction factors and viral accessory factors that overcome them can potentially be therapeutically useful. Preliminarily successful therapies – some of which are entering clinical trials – either inhibit the ability of virus to evade restriction factor-mediated immunity, or promote intracellular levels of restriction factors. These aims are achieved by multiple means, which are discussed. Summary: Many restriction factors appear to provide potentially useful targets for anti-HIV therapies, so time and interest should be invested in investigating ways to successfully therapeutically manipulate restriction factor-mediated immunity.