Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius. Issue 24 (15th December 2016)

• Record Type: Journal Article
• Authors: Jin, Qinghao; Lee, Jin Woo; Jang, Hari; Choi, Ji Eun; Kim, Hyung Sik; Lee, Dongho; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 24(2016)
• Page Start: 5995
• Page End: 5998
• Publication Date: 2016-12-15
• Subjects: Echinops latifolius -- Asteraceae -- Anti-inflammatory -- Dimeric sesquiterpene -- Thiophene; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.10.017
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1 ) and a new thiophene (2 ), along with six known compounds (3 –8 ). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods ( 1 H and 13 C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds4 and5 exhibited the most potent inhibitory effects on NO production.