Bifunctional RuII‐Complex‐Catalysed Tandem C−C Bond Formation: Efficient and Atom Economical Strategy for the Utilisation of Alcohols as Alkylating Agents. Issue 50 (31st October 2016)

• Record Type: Journal Article
• Authors: Roy, Bivas Chandra; Chakrabarti, Kaushik; Shee, Sujan; Paul, Subhadeep; Kundu, Sabuj
• Is Part Of: Chemistry. Volume 22:Issue 50(2016)
• Page Start: 18147
• Page End: 18155
• Publication Date: 2016-10-31
• Subjects: atom economical -- bifunctional catalysis -- catalysis -- C−C bond formation -- ruthenium; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201603557
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Catalytic activities of a series of functional bipyridine‐based Ru II complexes in β‐alkylation of secondary alcohols using primary alcohols were investigated. Bifunctional Ru II complex (3 a ) bearing 6, 6'‐dihydroxy‐2, 2'‐bipyridine (6DHBP) ligand exhibited the highest catalytic activity for this reaction. Using significantly lower catalyst loading (0.1 mol %) dehydrogenative carbon−carbon bond formation between numerous aromatic, aliphatic and heteroatom substituted alcohols were achieved with high selectivity. Notably, for the synthesis of β‐alkylated secondary alcohols this protocol is a rare one‐pot strategy using a metal–ligand cooperative Ru II system. Remarkably, complex3 a demonstrated the highest reactivity compared to all the reported transition metal complexes in this reaction. Abstract : Alcohols as alkylating agents : A rare example of highly efficient, atom economical and a greener strategy for the synthesis of a variety of β‐alkylated secondary alcohols with high selectivity is presented.