Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery. (7th February 2016)

• Record Type: Journal Article
• Authors: Fan, Mingliang; Liang, Xiaofei; Yang, Danbo; Pan, Xiaorong; Li, Zonghai; Wang, Hongyang; Shi, Bizhi
• Is Part Of: Journal of drug targeting. Volume 24:Number 2(2016)
• Page Start: 111
• Page End: 119
• Publication Date: 2016-02-07
• Subjects: Doxorubicin -- epidermal growth factor receptor -- GE11 -- micelles -- targeted drug delivery; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.3109/1061186X.2015.1058800
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo . The results indicated that GE11 conjugated phospholipid micelles should have potential applications in cancer therapy.