Controversial effect on Erk activation of some cytotoxic drugs in human LOVO colon cancer cells. (2nd January 2016)

• Record Type: Journal Article
• Authors: Jemel-Oualha, Ikram; Elloumi-Mseddi, Jihene; Beji, Abdelhamid; Hakim, Bochra; Aifa, Sami
• Is Part Of: Journal of receptor and signal transduction research. Volume 36:Number 1(2016)
• Page Start: 21
• Page End: 25
• Publication Date: 2016-01-02
• Subjects: Colorectal cancer -- ciprofloxacin -- Erk activation -- proliferation -- trimebutin maleate -- tiemonium methylsulfate; Cell receptors -- Periodicals; Cellular signal transduction -- Periodicals; 571.6
• DOI: 10.3109/10799893.2014.975246
• Languages: English
• ISSNs: 1079-9893

Abstract

Abstract: The use of some classic antibiotics was recently shown to inhibit growth and to induce apoptosis in human LOVO colon cancer cells. In this study, we describe that ciprofloxacin (CI), trimebutine maleate (COL) and tiemonium methylsulfate (VIS) greatly inhibit cell proliferation in vitro . Proliferation inhibition reached its maximum at 10 –4 M, 10 –3 M and 10 –2 M, respectively, for COL, CI and VIS. Moreover, phospho-extracellular-regulated kinase was totally abrogated in non-apoptotic cytotoxicity of VIS but decreases or increases in the apoptotic inhibition, respectively, of COL and CI treatments. Abbreviations: CI : ciprofloxacin;COL : trimebutine maleate;VIS : tiemonium methylsulfate;MAPK/Erk : mitogen-activated protein kinases/extracellular-regulated kinase