A robust and refillable magnetic sponge capsule for remotely triggered drug release. Issue 46 (8th November 2016)

• Record Type: Journal Article
• Authors: Shi, Jingru; Zhang, Hongbin; Jackson, John; Shademani, Ali; Chiao, Mu
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 46(2016)
• Page Start: 7415
• Page End: 7422
• Publication Date: 2016-11-08
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb02762h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A refillable sponge capsule was fabricated for controlled drug release with prolonged period triggered by external magnetic stimuli. Abstract : Numerous different delivery systems have been developed for local administration of drugs. However, their service lives generally depend on the payload depletion time and most of them are designed for one time use due to lack of drug replenishment abilities. To address this issue, a refillable magnetic porous polydimethylsiloxane (PDMS) capsule is proposed for remotely controlled drug delivery applications. An inner cavity is built in the sponge scaffold to provide space for drug storage and the refilling is accomplished by injecting drugs with a syringe. The rapid and reversible deformation of the magnetic porous structure under a magnetic field offers a controlled pumping force to push drugs out of the capsule. In this work, low molecular weight (methylene blue, MB, 320 g mol −1 ) and high molecular weight (bovine serum albumin, BSA, 67 000 g mol −1 ) molecules were used as model compounds to test and verify the operational principle. This proof-of-concept study has demonstrated the capability of the refillable porous capsule in controlled drug delivery under external magnetic stimuli.