Pressure controlled drug release in a Zr-cluster-based MOF. Issue 39 (16th September 2016)

• Record Type: Journal Article
• Authors: Jiang, Ke; Zhang, Ling; Hu, Quan; Zhao, Dian; Xia, Tifeng; Lin, Wenxin; Yang, Yanyu; Cui, Yuanjing; Yang, Yu; Qian, Guodong
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 39(2016)
• Page Start: 6398
• Page End: 6401
• Publication Date: 2016-09-16
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb01756h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A Zr-cluster-based MOFZJU-800 was synthesized with high drug loading capacity for controllable drug delivery from 2 days to 8 days. Abstract : A robust zirconium-cluster-based metal–organic framework (MOF)ZJU-800 with an excellent drug loading capacity (about 58.80 wt%) has been synthesized. The system shows an adjustable release time of the drug diclofenac sodium from 2 days to 8 days by controlling the degree of compaction between MOF and drug using pressure.