Three-step synthesis of l-ido-1-deoxynojirimycin derivatives by reductive amination in water, "borrowing hydrogen" under neat conditions and deprotection. Issue 40 (20th September 2016)

• Record Type: Journal Article
• Authors: Zhao, Kai; Zhou, Gang; Nie, Huifang; Chen, Weiping
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 40(2016)
• Page Start: 9466
• Page End: 9471
• Publication Date: 2016-09-20
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob01864e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A three-step synthesis ofl - ido -1-deoxynojirimycin derivatives, starting from readily available 2, 3, 4, 6-tetra- O -benzyl-d -glucopyranose via Ir-catalyzed reductive amination in water, "borrowing hydrogen" under neat conditions, and Pd-catalyzed debenzylation, is reported. Abstract : In this communication, we describe a three-step synthesis ofl - ido -1-deoxynojirimycin derivatives starting from readily available 2, 3, 4, 6-tetra- O -benzyl-d -glucopyranose via Ir-catalyzed reductive amination in water, "borrowing hydrogen" under neat conditions, and Pd-catalyzed debenzylation.