Expedited access to thieno[3, 2-c]quinolin-4(5H)-ones and benzo[h]-1, 6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method. Issue 46 (8th November 2016)

• Record Type: Journal Article
• Authors: Fang, Y.; Tranmer, G. K.
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 46(2016)
• Page Start: 10799
• Page End: 10803
• Publication Date: 2016-11-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02279k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Expedited access to substituted thieno[3, 2- c ]quinolin-4(5 H )-ones and benzo[ h ]-1, 6-naphthyridin-5(6 H )-ones via a continuous flow photocyclization method. Abstract : A single-step continuous flow method has been developed that gives expedited access to complex heterocycles via an intramolecular photochemical cyclization. Herein we report the first examples of the photochemically-induced generation of thieno[3, 2- c ]quinolin-4(5 H )-ones, 16 examples, and benzo[ h ]-1, 6-naphthyridin-5(6 H )-ones, 6 examples. Overall, the continuous flow method provides access to complex heterocycles in two steps from commercially available starting materials in good yields and with greater atom efficiency than traditional batch reactions.