NBS/DBU mediated one-pot synthesis of α-acyloxyketones from benzylic secondary alcohols and carboxylic acids. Issue 46 (9th November 2016)

• Record Type: Journal Article
• Authors: Zhu, Minghui; Wei, Wei; Yang, Daoshan; Cui, Hong; Cui, Huanhuan; Sun, Xuejun; Wang, Hua
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 46(2016)
• Page Start: 10998
• Page End: 11001
• Publication Date: 2016-11-09
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02173e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A simple and efficient NBS/DBU-mediated one-pot procedure has been developed for the synthesis of α-acyloxyketones from benzylic secondary alcohols and carboxylic acids. Abstract : A simple and efficient one-pot NBS/DBU-mediated method has been developed for the synthesis of α-acyloxyketones from various benzylic secondary alcohols and carboxylic acids. Through this methodology, a series of α-acyloxyketones could be obtained in good to excellent yields under mild conditions. Importantly, this new reaction avoids the direct usage of toxic metal catalysts or potentially dangerous peroxide oxidants.