Transition-metal-free oxidative C5 C–H-halogenation of 8-aminoquinoline amides using sodium halides. Issue 43 (18th October 2016)

• Record Type: Journal Article
• Authors: Wang, Ying; Wang, Yang; Jiang, Kai; Zhang, Qian; Li, Dong
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 43(2016)
• Page Start: 10180
• Page End: 10184
• Publication Date: 2016-10-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02079h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A simple and efficient transition-metal-free oxidative halogenation (Cl, Br) of the C5 C–H bond of 8-aminoquinoline amides, with low-cost and innoxious sodium halides, has been developed. Abstract : A simple and efficient transition-metal-free oxidative halogenation (Cl, Br) of the C5 C–H bond of 8-aminoquinoline amides has been developed. This method employed low-cost and innoxious sodium halides as halogenation reagents and oxone as an oxidant. The reactions demonstrated air and moisture tolerance, and good functional group compatibility, giving highly selective C5-halogenated products in good to excellent yields.