Copper-catalyzed oxidative cyclization of vinyl azides with benzylic Csp3–H bonds for the synthesis of substituted phenanthridines. Issue 41 (26th September 2016)

• Record Type: Journal Article
• Authors: Yang, Jun-Cheng; Zhang, Jin-Jiang; Guo, Li-Na
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 41(2016)
• Page Start: 9806
• Page End: 9813
• Publication Date: 2016-09-26
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02012g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A copper-catalyzed oxidative cyclization of vinyl azides with benzylic Csp 3 –H bonds via a tandem dual C–H functionalization process has been developed. This reaction allows access to substituted phenanthridines containing a variety of functional groups. Abstract : A copper-catalyzed oxidative cyclization of vinyl azides with benzylic Csp 3 –H bonds via a tandem dual C–H functionalization process has been developed. This procedure allows access to substituted phenanthridines containing a variety of functional groups. In addition to benzyl hydrocarbons, other substrates containing unactivated Csp 3 –H bonds, such as ethers and alkanes could also be applied successfully to this transformation.