Computation-guided improved one-pot synthesis of macrocyclic cation-binding aromatic pyridone pentamers. Issue 42 (21st September 2016)

• Record Type: Journal Article
• Authors: Zeng, Vicky Ziman; Su, Haibin; Li, Tianhu
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 42(2016)
• Page Start: 9961
• Page End: 9965
• Publication Date: 2016-09-21
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob01841f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The use of polar DMF to relax the H-bonding-rigidified backbone leads to significantly improved yields forBOP -mediated one-pot synthesis of pentameric macrocycles. Abstract : By using polar DMF to relax the H-bonded rigid backbone and to lower the energetic penalty associated with the sterically-crowded environment, the yields forBOP -mediated one-pot synthesis of pentameric macrocycles can be improved from 10–25% as obtained in CH2 Cl2 to 13–47% when 15% DMF in CH2 Cl2 was used as the reaction medium.