Design and functionalization of responsive hydrogels for photonic crystal biosensors. Issue 3 (10th May 2016)

• Record Type: Journal Article
• Authors: Jung, Sukwon; Kaar, Joel L.; Stoykovich, Mark P.
• Is Part Of: Molecular Systems Design and Engineering. Volume 1:Issue 3(2016)
• Page Start: 225
• Page End: 241
• Publication Date: 2016-05-10
• Subjects: Chemistry -- Molecular aspects -- Periodicals; Chemical engineering -- Molecular aspects -- Periodicals; Nanotechnology -- Periodicals; 620.5
• DOI: 10.1039/c6me00031b
• Languages: English
• ISSNs: 2058-9689

Abstract

Abstract : In this review, the molecular-level design and fabrication of photonic crystal hydrogels is presented, and their application as biosensors for many biologically important analytes is highlighted. Abstract : Photonic crystals embedded in analyte responsive hydrogels provide a powerful platform for biosensing and have benefitted from recent advances in polymer synthesis and functionalization, nanofabrication, and optical characterization. In this review, state-of-the-art techniques for the fabrication and functionalization of photonic crystal hydrogels are presented, along with a fundamental description of how such materials transduce detection of a target analyte into a simple optical readout. Specific biosensing applications using photonic crystal hydrogels are highlighted, including for the detection of DNA hybridization and single-site DNA modifications, enzyme activity, and small molecule metabolites. Moreover, perspectives on using molecular-level interactions to design and engineer more sensitive or more selective biosensors, as well as future directions in this expanding field, are discussed.