Copper-catalyzed cascade annulation between α-bromocarbonyls and biaryl or (Z)-arylvinylacetylenes enabling a direct synthesis of dibenzocycloheptanes and related compounds. Issue 97 (15th November 2016)

• Record Type: Journal Article
• Authors: Lu, Danyang; Wan, Yimei; Kong, Lichun; Zhu, Gangguo
• Is Part Of: Chemical communications. Volume 52:Issue 97(2016)
• Page Start: 13971
• Page End: 13974
• Publication Date: 2016-11-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc07727g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Copper-catalyzed cascade annulation of γ, δ-unsaturated α-bromocarbonyls with biaryl or ( Z )-arylvinylacetylenes is presented, giving an expeditious access to dibenzocycloheptanes and related compounds in moderate to high yields. Abstract : Copper-catalyzed cascade annulation of γ, δ-unsaturated α-bromocarbonyls with biaryl or ( Z )-arylvinylacetylenes is presented, giving an expeditious access to dibenzocycloheptanes and related compounds in moderate to high yields. It provides a novel method for the one-pot synthesis of cycloheptane and cycloheptene-fused polycyclic scaffolds featuring a rare 7- endo-trig radical cyclization.