Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)–H bonds. Issue 89 (20th October 2016)

• Record Type: Journal Article
• Authors: Pan, Jin-Long; Li, Quan-Zhe; Zhang, Ting-Yu; Hou, Si-Hua; Kang, Jun-Cheng; Zhang, Shu-Yu
• Is Part Of: Chemical communications. Volume 52:Issue 89(2016)
• Page Start: 13151
• Page End: 13154
• Publication Date: 2016-10-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc07885k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient and convenient method has been developed to achieve direct silylation of unactivated remote primary or secondary C(sp 3 )–H bonds to form C–Si bonds with hexamethyldisilane (HMDS). Abstract : An efficient and convenient method has been developed to achieve direct silylation of unactivated remote primary or secondary C(sp 3 )–H bonds to form C–Si bonds with hexamethyldisilane (HMDS). This method highlights the emerging strategy to transform unactivated methyl or methylene into versatile functional groups in organic synthesis and provides a new method to construct functionalized C–Si bonds for synthetic chemistry.