Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks. Issue 84 (4th October 2016)

• Record Type: Journal Article
• Authors: Caporaso, Roberta; Manna, Srimanta; Zinken, Sarah; Kochnev, Alexander R.; Lukyanenko, Evgeny R.; Kurkin, Alexander V.; Antonchick, Andrey P.
• Is Part Of: Chemical communications. Volume 52:Issue 84(2016)
• Page Start: 12486
• Page End: 12489
• Publication Date: 2016-10-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc07196a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A selective introduction of trideuteromethyl groups for the synthesis of labelled compounds under radical reaction conditions is demonstrated. Abstract : The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope of the developed method for the synthesis of various scaffolds was demonstrated.