Flavin-mediated photo-oxidation for the detection of mitochondrial flavins. Issue 92 (1st November 2016)

• Record Type: Journal Article
• Authors: Lee, Dong-Nam; Kim, Eunjin; Lee, Jae Hong; Kim, Jong Seung; Kang, Chulhun; Hong, Jong-In
• Is Part Of: Chemical communications. Volume 52:Issue 92(2016)
• Page Start: 13487
• Page End: 13490
• Publication Date: 2016-11-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc07483a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Photooxidation-based probe1 showed high selectivity for flavins and mitochondrial localization in live cells and tissues. Abstract : We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe1 showed high brightness ( ε × Φ f = 6.50 × 10 3 M −1 cm −1 ) at long wavelengths (maximum emission wavelength, λ max = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.