Chemodivergent synthesis of multi-substituted/fused pyrroles via copper-catalyzed carbene cascade reaction of propargyl α-iminodiazoacetates. Issue 84 (3rd October 2016)

• Record Type: Journal Article
• Authors: Zhang, Cheng; Chang, Sailan; Qiu, Lihua; Xu, Xinfang
• Is Part Of: Chemical communications. Volume 52:Issue 84(2016)
• Page Start: 12470
• Page End: 12473
• Publication Date: 2016-10-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc06864b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel cascade reaction via γ-imino carbene is developed, which provides access to pyrroles in high yield with structure diversity. Abstract : A novel cascade reaction of alkynyl-tethered α-iminodiazoacetates has been developed, which provides a general access to both multi-substituted and fused pyrroles in high yields with a broad substrate scope. The γ-imino carbene is proposed as the key intermediate in this divergent reaction and followed by unpresented transformations.