Glycosidase activated release of fluorescent 1, 8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes'. Issue 89 (27th September 2016)

• Record Type: Journal Article
• Authors: Calatrava-Pérez, Elena; Bright, Sandra A.; Achermann, Stefan; Moylan, Claire; Senge, Mathias O.; Veale, Emma B.; Williams, D. Clive; Gunnlaugsson, Thorfinnur; Scanlan, Eoin M.
• Is Part Of: Chemical communications. Volume 52:Issue 89(2016)
• Page Start: 13086
• Page End: 13089
• Publication Date: 2016-09-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc06451e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Glycosylated 4-amino-1, 8-naphthalimide derivatives can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide as a fluorescent imaging agent. Abstract : Glycosylated 4-amino-1, 8-naphthalimide derivatives possess a native glycosidic linkage that can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide as a fluorescent imaging or therapeutic agent. In vitro studies using a variety of cancer cell lines demonstrated that the naphthalimides only get taken up into cells upon enzymatic cleavage from the glycan unit; a mechanism that offers a novel approach for the targeted delivery of probes/drugs.