Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation. Issue 82 (23rd September 2016)

• Record Type: Journal Article
• Authors: Augurusa, Alessandra; Mehta, Meera; Perez, Manuel; Zhu, Jiangtao; Stephan, Douglas W.
• Is Part Of: Chemical communications. Volume 52:Issue 82(2016)
• Page Start: 12195
• Page End: 12198
• Publication Date: 2016-09-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc06914b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A catalytic methodology for the conversion of amides to amines is reported. Among the 25 examples, 14 reduce N -trifluoroacetamides to give trifluoroethylamines. Abstract : A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N -trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.