Synthesis and deposition of a Tröger's base polymer on the electrode surface for potentiometric detection of a neuroblastoma tumor marker metabolite. Issue 80 (19th September 2016)

• Record Type: Journal Article
• Authors: Shishkanova, T. V.; Havlík, M.; Dendisová, M.; Matějka, P.; Král, V.
• Is Part Of: Chemical communications. Volume 52:Issue 80(2016)
• Page Start: 11991
• Page End: 11994
• Publication Date: 2016-09-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc06203b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We propose an innovative approach to detect a low molecular weight metabolite of neuroblastoma. Abstract : The development of novel diagnostic tools is a primary goal in bioanalytical chemistry. Here we report the synthesis of Tröger's base functionalized with amino- and coumarin-units designed as a monomeric unit for the development of an electrochemical cancer sensor. The synthesized receptor was deposited onto a conducting support using electrochemical polymerization, characterized spectroscopically and tested potentiometrically towards metabolites used as tumor markers of neuroblastoma.