Nosocomial spread of Klebsiella pneumoniae isolates producing blaGES-4 carbapenemase at a Japanese hospital. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Yamasaki, Katsutoshi; Komatsu, Masaru; Ono, Tamotsu; Nishio, Hisaaki; Sueyoshi, Noriyuki; Kida, Kaneyuki; Satoh, Kaori; Toda, Hirofumi; Nishi, Isao; Akagi, Masahiro; Mizutani, Tetsu; Nakai, Isako; Kofuku, Tomomi; Orita, Tamaki; Zikimoto, Takuya; Nakamura, Tatsuya; Wada, Yasunao
• Is Part Of: Journal of infection and chemotherapy. Volume 23:Issue 1(2017:Jan.)
• Page Start: 40
• Page End: 44
• Publication Date: 2017-01
• Subjects: Nosocomial spread -- Carbapenemases -- GES-4; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2016.09.006
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: Six Klebsiella pneumoniae clinical isolates resistant to various cephalosporins and cephamycins were identified in a Japanese general hospital, a tertiary care hospital, between November 2009 and April 2010. All K. pneumoniae isolates carried bla GES-4 and bla SHV-1, while 2 K. pneumoniae isolates also harbored bla CTX-M-15 . The pulsed-field gel electrophoresis patterns revealed that these 6 K. pneumoniae isolates were almost identical, suggesting their clonal relatedness. Plasmid profiles and conjugation assays revealed that these bla GES-4 genes were located on similar conjugative plasmids. These data indicate that nosocomial spread caused by K. pneumoniae isolates producing bla GES-4 carbapenemase occurred at a Japanese general hospital. K. pneumoniae isolate harboring bla GES-4 is rarely reported in Japan, and, to the best of our knowledge, this is the second report of K. pneumoniae isolates harboring bla GES-4 that occurred nosocomial spread in Japan.