The good and the bad faces of STAT1 in solid tumours. (January 2017)

• Record Type: Journal Article
• Authors: Meissl, Katrin; Macho-Maschler, Sabine; Müller, Mathias; Strobl, Birgit
• Is Part Of: Cytokine. Volume 89(2017)
• Page Start: 12
• Page End: 20
• Publication Date: 2017-01
• Subjects: BAD Bcl2-associated agonist of cell death -- Bcl B-cell lymphoma -- CD cluster of differentiation -- CDK cyclin-dependent kinase -- CTL cytotoxic T lymphocyte -- CUG cancer upregulated gene -- CXCL C-X-C motive ligand -- DC dendritic cells -- DAMP danger-associated molecular pattern -- DR death receptor -- ER estrogen receptor -- ERBB2/neu Erb-B2 receptor tyrosine Kinase 2 -- ERK extracellular signal-regulated kinase -- FASL FAS ligand -- FADD Fas-associated protein with death domain -- FGF fibroblast growth factor -- HDAC histone deacetylase -- HIF hypoxia-inducible factor -- IFN interferon -- IFNAR IFNα/β receptor -- IFNGR IFNγ receptor -- IL interleukin -- IRDS IFN-related DNA damage resistance signature -- IRES internal ribosome entry site -- IRF interferon regulatory factor -- ISG interferon-stimulated gene -- JAK Janus kinase -- JNK c-Jun N-terminal kinase -- MCA methylcholanthrene -- MDM2 mouse double minute 2 homolog -- MDR multidrug resistance -- MDSC myeloid-derived suppressor cell -- MEF mouse embryonic fibroblast -- MHC class I major histocompatibility complex class I -- miRNA microRNA -- MMP matrix metalloproteinase -- MUC mucin -- NFκB nuclear factor kappa B -- NK natural killer -- PDCD programmed cell death -- PD-L1 programmed death-ligand 1 -- PIAS protein inhibitors of activated STATs -- PRR pattern recognition receptor -- pSTAT tyrosine phosphorylated STAT -- Rb retinoblastoma -- RIG-1 retinoic acid inducible gene 1 -- RIP receptor interacting protein kinase -- SHP2 SH2 domain-containing protein-tyrosine phosphatase -- SOCS suppressor of cytokine signalling -- STAT signal transducer and activator of transcription -- S727 serine 727 -- TAM tumour-associated macrophage -- TGF transforming growth factor -- TLR toll-like receptor -- TNBC triple negative breast cancer -- TNF tumour necrosis factor -- TRADD TNFR1-associated death domain protein -- TRAF TNF-receptor associated factor -- TRAIL TNF-related apoptosis-inducing ligand -- U-STAT unphosphorylated STAT -- VEGF vascular endothelial growth factor -- XIAP X-linked inhibitor of apoptosis protein -- Y701 tyrosine 701; Tumour suppressor -- Immune surveillance -- Cytokine signalling -- Cell proliferation and death -- Acquired therapy resistance; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.11.011
• Languages: English
• ISSNs: 1043-4666

Abstract

Abstract: Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase (JAK)/STAT signalling cascade and is best known for its essential role in mediating responses to all types of interferons (IFN). STAT1 regulates a variety of cellular processes, such as antimicrobial activities, cell proliferation and cell death. It exerts important immune modulatory activities both in the innate and the adaptive arm of the immune system. Based on studies in mice and data from human patients, STAT1 is generally considered a tumour suppressor but there is growing evidence that it can also act as a tumour promoter. This review aims at contrasting the two faces of STAT1 in tumourigenesis and providing an overview on the current knowledge of the underlying mechanisms or pathways.