Access to 2‐Arylindoles via Decarboxylative C−C Coupling in Aqueous Medium and to Heteroaryl Carboxylates under Base‐Free Conditions using Diaryliodonium Salts. Issue 23 (7th November 2016)

• Record Type: Journal Article
• Authors: Arun, Velladurai; Pilania, Meenakshi; Kumar, Dalip
• Is Part Of: Chemistry, an Asian journal. Volume 11:Issue 23(2016)
• Page Start: 3345
• Page End: 3349
• Publication Date: 2016-11-07
• Subjects: arylation -- C−C coupling -- diaryliodonium salt -- heterocycles -- homogeneous catalysis; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201601290
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Easily accessible heteroaromatic carboxylic acids and diaryliodonium salts were successfully employed to construct valuable 2‐arylindoles and heteroaryl carboxylates in a regioselective fashion. C2‐arylated indoles were produced using a Pd‐catalyzed decarboxylative strategy in water without any base, oxidant, or ligand. Heteroaryl carboxylates were prepared under metal and base‐free conditions. This protocol was successfully utilized to synthesize Paullone, a cyclin‐dependent kinase (CDK) inhibitor. Abstract : Two birds, one stone : Diaryliodonium salts have been successfully employed to construct 2‐arylindoles and heteroaryl carboxylates. The indoles are prepared using decarboxylative C−C coupling strategy in water. The carboxylates are produced under base‐free conditions.