Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. (4th March 2016)

• Record Type: Journal Article
• Authors: Ma, T. ‐J.; Zhang, X. ‐J.; Ding, X. ‐P.; Chen, H. ‐H.; Zhang, Y. ‐W.; Ding, M.
• Is Part Of: Andrologia. Volume 48:Number 10(2016)
• Page Start: 1253
• Page End: 1260
• Publication Date: 2016-03-04
• Subjects: Idiopathic infertility -- polymorphisms -- time‐of‐flight mass spectrometry -- UBR2 gene; Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.12569
• Languages: English
• ISSNs: 0303-4569

Abstract

Summary: The associations between three single nucleotide polymorphisms (SNPs; rs3749897, rs16895863 and rs373341) of UBR2 gene and idiopathic aspermia or oligospermia were investigated in this study by a case–control experiment with 149 fertile and 316 infertile men, including 244 patients with idiopathic aspermia and 72 patients with severe oligospermia. The time‐of‐flight mass spectrometry (Sequenom MassARRAY ® system) was used in this study. A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171–6.525; P = 0.017), which could indicate that the combined AT‐TC‐CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.