DNA‐Nanostructure–Gold‐Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy. Issue 45 (28th September 2016)

• Record Type: Journal Article
• Authors: Du, Yang; Jiang, Qiao; Beziere, Nicolas; Song, Linlin; Zhang, Qian; Peng, Dong; Chi, Chongwei; Yang, Xin; Guo, Hongbo; Diot, Gaël; Ntziachristos, Vasilis; Ding, Baoquan; Tian, Jie
• Is Part Of: Advanced materials. Volume 28:Issue 45(2016)
• Page Start: 10000
• Page End: 10007
• Publication Date: 2016-09-28
• Subjects: cancer -- DNA origami -- gold nanorods -- optoacoustic imaging -- photoacoustic imaging -- photothermal therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201601710
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : A functional cancer theranostic nanoplatform is developed, specifically tailored toward the optoacoustic modality by combining gold nanorods with DNA nanostructures (D–AuNR). DNA origami is used as an efficient delivery vehicle owing to its prominent tumor‐targeting property. The D–AuNR hybrids display an enhanced tumor diagnostic sensitivity by improved optoacoustic imaging and excellent photothermal therapeutic properties in vivo.