Theoretical modeling expressions for networked enzymatic signal processing steps as logic gates optimized by filtering. Issue 1 (2nd January 2017)

• Record Type: Journal Article
• Authors: Privman, Vladimir
• Is Part Of: International journal of parallel, emergent and distributed systems. Volume 32:Issue 1(2017)
• Page Start: 30
• Page End: 43
• Publication Date: 2017-01-02
• Subjects: Binary AND -- biocatalytic cascade -- biochemical signals -- multi-input biosensor; Parallel computers -- Periodicals; Electronic data processing -- Distributed processing -- Periodicals; Computer algorithms -- Periodicals; 004.35
• DOI: 10.1080/17445760.2016.1140167
• Languages: English
• ISSNs: 1744-5760

Abstract

Abstract: We describe modeling approaches to a 'network' of connected enzyme-catalyzed reactions, with added (bio)chemical processes that introduce biochemical filtering steps into the functioning of such a biocatalytic cascade. Theoretical expressions are derived that allow simple, few-parameter modeling of processes concatenated in such cascades, both with and without filtering. The modeling approach captures and explains features identified in earlier studies of enzymatic processes considered as potential 'network components' for multi-step information/signal processing systems.