The Value of Mitotic Count and Ki67 Proliferation Index in Congenital Mesoblastic Nephroma. (1st November 2016)

• Record Type: Journal Article
• Authors: Apaydin, Evsen; Ozluk, Yasemin; Yuksel, Secil; Erginel, Basak; Tugcu, Deniz; Celik, Alaaddin; Kilicaslan, Isin
• Is Part Of: Fetal and pediatric pathology. Volume 35:Number 6(2016)
• Page Start: 376
• Page End: 384
• Publication Date: 2016-11-01
• Subjects: mesoblastic nephroma -- pediatric -- renal tumor -- mitosis -- Ki-67; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2016.1207731
• Languages: English
• ISSNs: 1551-3815

Abstract

ABSTRACT: Objective : We aimed to define the histopathologic features and proliferative rate of congenital mesoblastic nephroma (CMN) as a risk factor for recurrence. Methods : Fourteen cases of CMN among 138 registered pediatric renal tumors were retrospectively reviewed. The prognostic impact for mitotic rate and Ki67 index was investigated. Results : There were four (28.6%) classic, six (42.9%) cellular, and four (28.6%) mixed type CMNs, with average Ki-67 counts of 16.75% in the classic CMN, and 53.2% in the tumors with cellular components (both mixed and cellular CMNs). Twelve patients (85.7%) were aged less than six months. Tumors with cellular component showed significantly larger tumor diameter and higher Ki-67 index ( p = 0.015 and p = 0.016, respectively). The patient with cellular CMN, whose tumor showed the highest mitotic rate (4.9/HPF), but not the highest Ki67 index (57.4%), died of recurrent disease with distant metastasis. Conclusion : Proliferative markers-mitotic count and Ki67 index-have limited value to predict recurrence or metastasis in CMNs with a cellular component.