Estimating relative bioavailability of soil lead in the mouse. Issue 24 (16th December 2016)

• Record Type: Journal Article
• Authors: Bradham, Karen D.; Green, William; Hayes, Hunter; Nelson, Clay; Alava, Pradeep; Misenheimer, John; Diamond, Gary L.; Thayer, William C.; Thomas, David J.
• Is Part Of: Journal of toxicology and environmental health. Volume 79:Issue 24(2016)
• Page Start: 1179
• Page End: 1182
• Publication Date: 2016-12-16
• Subjects: Toxicology -- Periodicals; Environmental health -- Periodicals; 615.90205
• DOI: 10.1080/15287394.2016.1221789
• Languages: English
• ISSNs: 1528-7394

Abstract

ABSTRACT: Lead (Pb) in soil is an important exposure source for children. Thus, determining bioavailability of Pb in soil is critical in evaluating risk and selecting appropriate strategies to minimize exposure. A mouse model was developed to estimate relative bioavailability of Pb in NIST SRM 2710a (Montana 1 Soil). Based on Pb levels in tissues, the mean relative bioavailability of this metal in this soil was 0.5. Estimates of relative bioavailabilities derived from mouse compared favorably with those obtained in juvenile swine. The mouse model is thus an efficient and inexpensive method to obtain estimates of relative bioavailability of soil Pb.