Subclinical hypothyroidism is associated with metabolic syndrome and clomiphene citrate resistance in women with polycystic ovary syndrome. (2nd October 2016)

• Record Type: Journal Article
• Authors: Lu, Yue-Hong; Xia, Zhou-Lan; Ma, Ying-Ying; Chen, Hui-Juan; Yan, Li-Ping; Xu, Hui-Fang
• Is Part Of: Gynecological endocrinology. Volume 32:Number 10(2016:Oct.)
• Page Start: 852
• Page End: 855
• Publication Date: 2016-10-02
• Subjects: CC resistance -- IR -- MS -- PCOS -- SCH; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2016.1183193
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Background: To evaluate the possible relationship between subclinical hypothyroidism (SCH) and metabolic syndrome (MS) and the response to clomiphene citrate (CC) stimulation in women with polycystic ovary syndrome (PCOS). Methods: One hundred and ninety-six women with PCOS were divided into two groups: (1) the SCH group with 92 patients; (2) the euthyroid (EU) group with 104 patients. Physical characteristics and metabolic parameters as well as the reaction to CC stimulating test were compared between these two groups. Results: (1) In the SCH group, significantly higher body mass index, Ferriman–Gallwey score, serum triglyceride, insulin and glucose of oral glucose tolerance test, homeostatic model assessment-insulin resistance (HOMA-IR) and significantly lower serum high-density lipoprotein cholesterol was observed in comparison with those in the EU group ( p < 0.05). (2) The prevalence of CC resistance (30.4%), IR (43.5%) and MS (34.8%) in the SCH group was significantly higher than that in the EU group ( p < 0.05). Conclusions: SCH was found associated with IR, MS and CC resistance in women with PCOS. PCOS patients with SCH may have a poorer treatment response to ovulation induction with CC.