Decreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas. (2nd January 2017)

• Record Type: Journal Article
• Authors: Costello, Leslie C.; Franklin, Renty B.
• Is Part Of: Expert opinion on therapeutic targets. Volume 21:Number 1(2017:Jan.)
• Page Start: 51
• Page End: 66
• Publication Date: 2017-01-02
• Subjects: ZIP transporters -- decreased zinc carcinomas -- prostate cancer -- hepatocellular carcinoma -- zinc treatment; Drugs -- Research -- Periodicals; 615.072
• DOI: 10.1080/14728222.2017.1265506
• Languages: English
• ISSNs: 1744-7631

Abstract

ABSTRACT: Introduction : Efficacious chemotherapy does not exist for treatment or prevention of prostate, liver, and pancreatic carcinomas, and some other cancers that exhibit decreased zinc in malignancy. Zinc treatment offers a potential solution; but its support has been deterred by adverse bias. Areas covered : 1. The clinical and experimental evidence for the common ZIP transporter/Zn down regulation in these cancers. 2. The evidence for a zinc approach to prevent and/or treat these carcinomas. 3. The issues that introduce bias against support for the zinc approach. Expert opinion : ZIP/Zn downregulation is a clinically established common event in prostate, hepatocellular and pancreatic cancers. 2. Compelling evidence supports the plausibility that a zinc treatment regimen will prevent development of malignancy and termination of progressing malignancy in these cancers; and likely other carcinomas that exhibit decreased zinc. 3. Scientifically-unfounded issues that oppose this ZIP/Zn relationship have introduced bias against support for research and funding of a zinc treatment approach. 4. The clinically-established and supporting experimental evidence provide the scientific credibility that should dictate the support for research and funding of a zinc approach for the treatment and possible prevention of these cancers. 5. This is in the best interest of the medical community and the public-at-large.